Hypoglycemia Diabetes

Vanadyl sulfate is one of the supplements I recommend to help control blood sugar because it mimics the action of insulin and helps with glucose uptake in cells. But despite its amazing benefits, I find that questions about its safety periodically come up. 

Take, for example, a note I received from a reader in Oklahoma City not too long ago. Although he was taking vanadyl sulfate to control blood sugar, he’d heard that it could also cause green tongue and other problems. I’m happy to answer this concern, because it pops up from time to time.

Vanadyl sulfate is a stable, inorganic form of vanadium, a metallic element used primarily as an additive in steel production. Acute exposure to the dust or fumes of vanadium or various vanadium compounds can certainly be toxic to the nervous and respiratory systems, liver, and other organs. And “green tongue” (as the name suggests, a greenish discoloration of the tongue) is indeed a classic symptom of toxicity in miners, industrial workers, or others exposed to high levels of vanadium.

But the accusation—often repeated on the Internet and elsewhere—that nutritional supplements containing minute amounts of vanadyl sulfate are toxic, is completely unfounded. On the contrary, studies demonstrate that vanadyl sulfate is safe when taken in doses of 75, 150, and even 300 mg per day for prolonged periods. Some study subjects taking the higher dosage reported gastrointestinal disturbances, but this resolved over the study course.

What these studies do show—and there are hundreds of them, some dating back more than 20 years—are profound benefits. In average doses of 100–150 mg, vanadyl sulfate increases insulin sensitivity and helps lower blood sugar and hemoglobin A1C—without danger of hypoglycemia. It has even been shown to reduce insulin requirements in individuals with type 1 diabetes. But what I find most remarkable is that benefits usually endured after the supplement was discontinued, suggesting that vanadyl sulfate has an ameliorating effect on the underlying diabetic condition.

So why do rumors of toxicity persist, despite the fact that vanadyl sulfate is, hands down, much safer than the scores of FDA-approved type 2 diabetes treatments? A cynic might say it’s because widespread use would cut into the enormous profits reaped by the pharmaceutical companies—not to mention that a number of vanadium compounds are in the pipeline. Whatever the reason, I stand by my recommendations for patients dealing with diabetes: 100–150 mg of vandyl sulfate daily along with other targeted nutrients, a low-glycemic diet, exercise after every meal, and weight loss. You can take it with confidence.