From CNN: Avandia and diabetes: Was revolution worth the risks?"A decade after critics first accused the Food and Drug Administration of downplaying side effects from Avandia, the agency says it will reveal on Friday the data it is reviewing ahead of an advisory panel meeting about the safety of the popular diabetes drug.
The meeting, scheduled for July 13 and 14, comes on the heels of two new studies suggesting that Avandia may cause serious or even life-threatening heart problems -- and a third study that seems to show just the opposite.
When the gavel comes down at the end, it could bring down the curtain on the troubled 11-year run of one of the pharmaceutical industry's biggest hits. Along the way, Avandia has left a trail of admirers who see it as revolutionizing diabetes care, along with critics who say the company oversold benefits while misleading patients and doctors about serious side effects."
Dr. Whitaker's TakeDr. Whitaker has railed against Avandia in no less than nine different
Health & Healing newsletter articles, dating as far back as March 2007. In fact, in May 2008, he wrote, "Another class of diabetes drugs, and the second-most widely used type of medication by ACCORD participants, was thiazolidinediones, the most notorious of which is Avandia. If you want to increase your risk of heart attack by 40 percent, heart failure by 60 percent, and death by more than 30 percent, Avandia is the drug for you."
His take on the recent news?
"We’ve known for years that this drug is killing people. Label warnings are not enough. The FDA should take Avandia off the market."
With all the focus on “fixing” diabetes with drugs, underlying causes of the condition are rarely considered. One potential contributor is low testosterone, which affects one in three men managing diabetes. But which came first, testosterone deficiency or diabetes?
A study published in Diabetes Care may answer that question. Finnish researchers measured levels of sex hormone–binding globulin (SHBG) and testosterone in 702 middle-aged men who had no signs of diabetes and were easily able to maintain blood sugar levels that were healthy. They then reexamined them after 11 years.
At the time of follow-up, 147 had developed metabolic syndrome and 57 had diabetes. What’s important about this study is that, regardless of other factors, the men with the lowest testosterone levels were nearly two-and-a-half times more likely to have developed diabetes or metabolic syndrome.
The idea that diabetes can be treated by normalizing testosterone levels is one of the many alternative treatments for diabetes that is picking up speed. Studies looking at supplemental testosterone as an adjunct therapy are being conducted, and many physicians who use bioidentical hormones have been treating diabetes patients with it for years.
Men over the age of 45 should have their testosterone level tested. If it’s low, replacement should be considered. In addition to regulating insulin, testosterone reduces body fat, increases libido, boosts energy levels, and improves mood and memory. Testosterone requires a prescription and may be obtained from compounding pharmacies.
With all the focus on treating diabetes with drugs, underlying causes of the condition are rarely considered. One potential contributor is low testosterone, which affects one in three diabetic men. But which came first, testosterone deficiency or diabetes? A study published in Diabetes Care may answer that question.
Finnish researchers measured levels of sex hormone–binding globulin (SHBG) and testosterone in 702 middle-aged men who had no blood sugar problems, and then reexamined them after 11 years.
At the time of follow-up, 147 had developed metabolic syndrome and 57 were living with diabetes. What’s important about this study is that regardless of other factors, the men with the lowest testosterone levels were nearly two and a half times more likely to have developed diabetes or metabolic syndrome.
The idea of treating diabetes by normalizing testosterone levels is picking up speed. A study looking at supplemental testosterone as an adjunct therapy is underway, and many physicians who use bioidentical hormones have been treating patients with it for years.
If you are male and over the age of 45, get your testosterone level tested. If it’s low, replacement should be considered. In addition to regulating insulin and making it easier to control blood sugar, testosterone reduces body fat, increases libido, boosts energy levels, and improves mood and memory. Testosterone requires a prescription and may be obtained from compounding pharmacies.
Numerous scientific studies support safe, natural remedies for diabetes. Yet the vast majority of physicians continue to ignore the research—and jeopardize the health of patients seeking to manage diabetes—by focusing strictly on lowering blood sugar, no matter what the cost.
Part of the problem can be laid at the feet of human psychology. When a doctor sees a patient living with diabetes, specifically type 2 diabetes, he or she may give lip service to diet and exercise. But, to be really effective, the doctor must become a counselor who encourages and monitors the patient’s activity level, diet, and weight.
Obviously, lifestyle changes require work on the part of both physician and patient, and who wants to put forth that much effort? So the doc pulls out his prescription pad and discharges that responsibility. And patients accept this because it’s an easy out for them as well. What could be simpler than taking a “magic pill,” especially if adverse side effects are glossed over, as they usually are?
The pharmaceutical industry also shoulders much of the blame. These companies currently control the bulk of medical research, treatment guidelines, and physician education. As a result, not only is the effectiveness of drugs overstated and the risks minimized, but the emphasis on medication draws attention away from safe, natural treatments that truly improve the health and longevity of people managing diabetes.
Last week I talked about the studies that illustrate the dangers of diabetes drugs. Yes, these medications do lower blood sugar, but that shouldn’t be the main goal of managing diabetes. What good is a therapy that can lower blood sugar if it increases your risk of heart attack and death from cardiovascular disease?
Unfortunately, the vast majority of physicians ignore this research—and jeopardize the health of trusting patients. The pharmaceutical industry shoulders much of the blame because they control the bulk of medical research, treatment guidelines, and physician “education.” As a result, not only is the effectiveness of drugs overstated and the risks minimized, but the emphasis on medication draws attention away from safe, natural therapies that truly improve health and longevity.
These therapies, which include weight loss and lifestyle changes, require work on the part of both physician and patient. Most doctors do recommend diet and exercise, but to be really effective, this requires ongoing counseling and monitoring of activity, diet, and weight. Many physicians just don’t have the time or desire to put forth that much effort. And patients accept this because it’s an easy out for them as well. What could be simpler than taking a “magic pill”?
If not drugs, then what? Here’s the treatment program we recommend at the Whitaker Wellness Institute for our patients with type 2 diabetes.
Weight Loss: Losing weight is the single best therapy for type 2 diabetes. Unfortunately, there are no shortcuts to weight loss. It requires diet changes, an exercise program, and determination.
Diet: The most therapeutic diet for diabetes is a low-glycemic, Mediterranean-style menu with lots of vegetables and lean protein, such as fish and poultry; modest amounts of fruit (one serving per day); and healthful fats like olive oil. Stay away from sugar and starches—bread, pasta, cereals, and other grain-based foods drive up blood sugar and increase appetite.
Exercise: I recommend a brisk 10-minute walk after meals and several sessions of resistance exercise weekly. Walking and other forms of aerobic exercise lower blood sugar and burn calories, while resistance exercise builds muscle and improves long-term insulin sensitivity.
Nutritional Supplements: To guard against complications of the blood vessels, nerves, eyes, and kidneys, take a potent, antioxidant-rich daily multivitamin to replace the nutrients that are inevitably lost as a result of the diabetic condition. To lower blood sugar, take vanadyl sulfate 100 mg, alpha lipoic acid 400-800 mg, chromium 200 mcg, cinnamon 500–1,000 mg, and Gymnema sylvestre 400 mg daily. These supplements may be taken individually or in combination formulas.
My book Reversing Diabetes outlines a step-by-step program for treating diabetes. You can order it at www.amazon.com or by calling (800) 810-6655.
As the General Manager of Forward Nutrition, I'm constantly reading and researching about supplements and health, particularly when it involves diabetes. Diabetes and Metabolic Syndrome are huge problems that are only getting worse in this country, and natural treatments for diabetes don't get nearly the attention they deserve.
This article from the April 2009 issue of Nutritional Outlook (ok, I'm a little behind) is too good not to share.
Entitled "Understanding a Silent Killer," this is must reading if you're at all concerned about diabetes, maintaining or managing blood sugar, or seeking natural, safe treatments to treat Type 2 diabetes.
Among the natural treatments for diabetes care discussed are alpha-lipoic acid, dietary fiber, gymnema sylvestre and chromium. These nutrients have been shown repeatedly to help manage blood sugar, control blood sugar spikes, and reduce sugar cravings and mood swings.
Alpha-lipoic acid doesn't just improve insulin sensitivity, but also protects against diabetic complications like peripheral nerve pain. It's one of the best natural diabetes treatments, and it also helps your body utilize the other antioxidants you take, like vitamins C and E.
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